Modulates the immune system, studied for its potential in treating various autoimmune diseases and infections.

Common Name:
Thymosin Alpha-1

Compound Name:
Thymosin Alpha-1

Chemical Formula:
C129H215N33O55

Molecular Weight:
3108.3 g/mol

Sequence and Amino Acid Composition:

• Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
• Amino Acid Profile:
  • Serine (S):
    • Frequency: Multiple
    • Properties: Polar, participates in the formation of hydrogen bonds
    • Role in the Peptide: Important for the biological activity and stability of the peptide.
  • Glutamine (E) and Lysine (K):
    • Frequencies: Multiple
    • Properties: Glutamine is polar and Lysine is positively charged
    • Role in the Peptide: Essential for immune modulation and enhances the peptide’s ability to stimulate the immune response.
  • Aspartic Acid (D) and Alanine (A):
    • Frequencies: Multiple
    • Properties: Aspartic acid is acidic and polar; Alanine is non-polar and small
    • Role in the Peptide: Contribute to the structural features that allow proper interaction with immune cells.

Structure:
Thymosin Alpha-1 is a peptide consisting of 28 amino acids. It is derived from prothymosin alpha and plays a crucial role in the regulation of immune function.

Synthesis Method:
Synthesized through solid-phase peptide synthesis, which ensures high purity and allows for precise sequence accuracy.

Solubility:
Soluble in water and most aqueous buffers, facilitating its use in various pharmaceutical formulations.

Stability:
Stable under refrigeration (2-8°C) in lyophilized form. When reconstituted, it should be used within a short period to maintain its biological activity.

Function:
Thymosin Alpha-1 enhances the maturation, differentiation, and activation of T-cells, natural killer cells, and dendritic cells, making it critical for immune response modulation.

Benefits and Uses:

• Used in the treatment of chronic hepatitis B and C, enhancing the immune response to the virus.
• Investigated for potential use in cancer therapy, as it can boost the immune system’s ability to fight tumors.
• Explored for its effectiveness in increasing vaccine efficacy, particularly in the elderly and immunocompromised patients.

Side Effects:
Well-tolerated in most patients, with few reported side effects. Possible side effects include mild injection site reactions and transient flu-like symptoms.

Regulatory Status:
Approved in some countries for the treatment of hepatitis B and C and other conditions where immune response modulation is beneficial.

ARTICLES

EXERCISES

COMMUNITY