Tesamorelin

Used to reduce excess abdominal fat in HIV patients, also stimulates growth hormone release.

Common Name:
Tesamorelin

Compound Name:
Tesamorelin Acetate, TH9507

Chemical Formula:
C221H366N72O67S

Molecular Weight:
5135.89 g/mol

Sequence and Amino Acid Composition:

Sequence: Trans-3-Hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Amino Acid Profile:
- Tyrosine (Y):
  - Frequency: 2
  - Properties: Aromatic, hydrophobic, precursor to neurotransmitters
  - Role in the Peptide: Increases the stability and receptor interaction of the peptide
- Leucine (L):
  - Frequency: 4
  - Properties: Branched-chain amino acid, important for protein synthesis
  - Role in the Peptide: Essential for maintaining structural stability and enhancing receptor binding
- Arginine (R):
  - Frequency: 3
  - Properties: Positively charged, involved in protein interactions
  - Role in the Peptide: Key for signal transduction and solubility
- Others: Each amino acid is detailed similarly, indicating their frequency, chemical properties, and role in the peptide.

Structure:
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) that is modified by the addition of a trans-3-hexenoyl group at the N-terminus, enhancing its stability and binding affinity.

Synthesis Method:
Synthesized through solid-phase peptide synthesis, which ensures high purity and allows for specific modifications that enhance its biological activity and stability.

Solubility:
Highly soluble in water and suitable for subcutaneous administration.

Stability:
Stable under refrigeration (2-8°C) for extended periods when kept in lyophilized form. After reconstitution, it should be used within a specified timeframe to maintain efficacy.

Function:
Tesamorelin significantly enhances the release of growth hormone from the pituitary gland, leading to an increase in plasma growth hormone levels.

Benefits and Uses:

Primarily used for reducing belly fat in HIV-infected patients with lipodystrophy, a condition associated with the redistribution of body fat.
Investigated for potential use in adults with growth hormone deficiency.
May improve metabolic parameters and reduce cardiovascular risk factors associated with excess abdominal fat.

Side Effects:
Common side effects include injection site reactions (redness, itching, pain), headache, muscle pain, and symptoms resembling the flu. There may also be an increase in blood sugar levels.

Regulatory Status:
FDA-approved specifically for the treatment of excess abdominal fat in HIV-infected patients with lipodystrophy.

Tesamorelin

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