Sermorelin (Sermorelin Acetate, GRF 1-29)

A synthetic peptide that stimulates the release of growth hormone, studied for anti-aging and growth disorders.

Common Name:
Sermorelin

Compound Name:
Sermorelin Acetate, GRF 1-29

Chemical Formula:
C149H246N44O42S

Molecular Weight:
3357.88 g/mol

Sequence and Amino Acid Composition:

Sequence: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Amino Acid Profile:
- Tyrosine (Y):
  - Frequency: 2
  - Properties: Aromatic, hydrophobic, precursors to neurotransmitters
  - Role in the Peptide: Enhances peptide stability and increases hormone receptor interaction
- Leucine (L):
  - Frequency: 4
  - Properties: Branched-chain amino acid, important for protein synthesis
  - Role in the Peptide: Critical for maintaining the structural stability of the peptide and enhancing binding affinity to the receptor
- Arginine (R):
  - Frequency: 3
  - Properties: Positively charged, involved in protein interactions
  - Role in the Peptide: Essential for signal transduction and peptide solubility
- Other Amino Acids: Detailed similarly, indicating their frequency, chemical properties, and specific roles in the peptide.

Structure:
Sermorelin is a synthetic analog of the naturally occurring Growth Hormone-Releasing Hormone (GHRH). Its structure is designed to mimic the first 29 amino acids of the natural GHRH, which are essential for its biological activity.

Synthesis Method:
Synthesized through solid-phase peptide synthesis, allowing precise amino acid sequence arrangement and high purity.

Solubility:
Soluble in water and most aqueous buffers, facilitating easy administration.

Stability:
Sensitive to light and heat. Recommended storage in a lyophilized form at -20°C, protected from light. Once reconstituted, it should be used within a short period to maintain potency.

Function:
Sermorelin acts as a potent stimulator of growth hormone production from the anterior pituitary gland. It binds to the GHRH receptor, mimicking the effects of natural GHRH.

Benefits and Uses:

Enhances growth hormone levels in the body, leading to increased muscle mass, decreased body fat, improved energy levels, and enhanced tissue repair.
Used clinically for the diagnosis and treatment of growth hormone deficiency in children and as an anti-aging treatment in adults.
Has potential benefits in improving sleep patterns, enhancing recovery from injuries, and boosting overall metabolic rates.

Side Effects:
Possible side effects can include injection site reactions, headaches, flushing, hyperactivity, and in some cases, antibody formation that may reduce its effectiveness.

Regulatory Status:
FDA-approved for diagnostic evaluation of pituitary function and also for increasing growth hormone in deficient pediatric patients.

Sermorelin (Sermorelin Acetate, GRF 1-29)

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