A non-peptide compound that stimulates growth hormone release, studied for its potential in muscle wasting and growth hormone deficiency.
Common Name:
MK-677, Ibutamoren
Compound Name:
Ibutamoren Mesylate
Chemical Formula:
C27H36N4O5S
Molecular Weight:
528.67 g/mol
Sequence and Amino Acid Composition:
- Not applicable: MK-677 is not a peptide but rather a non-peptidic, selective and potent agonist of the ghrelin receptor.
Structure:
MK-677 is a small molecule that mimics the action of ghrelin, a hormone associated with hunger and the release of growth hormone (GH). It has a molecular structure that allows it to functionally mimic the ghrelin receptor, leading to increased growth hormone levels.
Synthesis Method:
Chemically synthesized as a small molecule, distinct from peptide synthesis methods used for compounds like GHRP-6 or CJC-1295.
Solubility:
Soluble in aqueous solutions at physiologically relevant pH levels.
Stability:
Stable at room temperature, making it suitable for storage and handling under normal conditions.
Function:
MK-677 binds to ghrelin receptors in the brain, mimicking the action of ghrelin. It increases the secretion of growth hormone and insulin-like growth factor 1 (IGF-1) without affecting cortisol levels.
Benefits and Uses:
- Promotes an increase in lean body mass and potentially bone density.
- Used in research settings for its potential to treat growth hormone deficiencies and muscle wasting diseases.
- Investigated for its anti-aging properties and effects on sleep quality, appetite stimulation, and cognitive function.
Side Effects:
Common side effects include increased appetite, mild lower extremity edema, and muscle pain. It may also raise fasting blood glucose levels and potentially affect insulin sensitivity, which requires monitoring in long-term use.
Regulatory Status:
Not approved by the FDA for medical use; primarily used in research and bodybuilding communities.
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