A small peptide known for its potential to enhance cognitive function and promote neurogenesis. It is studied for its ability to improve memory and learning by facilitating synaptic connectivity.
Common Name:
Dihexa
Compound Name:
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
Chemical Formula:
C27H44N6O5
Molecular Weight:
520.67 g/mol
Sequence and Amino Acid Composition:
- Not applicable: Dihexa is not a traditional peptide but a small molecule derivative designed to mimic certain peptide interactions.
Structure:
Dihexa is a synthetic compound structured to cross the blood-brain barrier and engage in high-affinity binding with hepatocyte growth factor (HGF) and its receptor, c-Met. It acts as an angiotensin IV analog with modifications to enhance stability and biological activity.
Synthesis Method:
Synthesized chemically as a small molecule with peptide-like properties to ensure precise molecular structure and high activity levels.
Solubility:
Soluble in water and most organic solvents, which facilitates its use in various experimental and therapeutic formulations.
Stability:
Stable under normal storage conditions; however, it should be stored in a cool, dry place away from light to maintain potency.
Function:
Dihexa is known for its potent neurogenic properties. It promotes neuronal growth and differentiation by simulating the action of HGF, which is critical in brain development and repair processes. This action is linked to enhanced cognitive function and potential recovery from neurological injuries.
Benefits and Uses:
- Investigated for its potential to treat neurodegenerative diseases such as Alzheimer’s disease, due to its ability to facilitate synaptic connectivity and neurogenesis.
- Potential applications in brain injury recovery, enhancing cognitive function and synaptic plasticity.
- Studied for its effects on learning and memory enhancement in aging populations.
Side Effects:
As a research chemical, detailed side effect profiles are not fully established. Preliminary studies suggest it is well-tolerated, but long-term safety and potential neurologic impacts need further investigation.
Regulatory Status:
Currently not approved by any major regulatory body for clinical use; primarily utilized in research settings.
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