CJC-1295

A long-acting growth hormone-releasing hormone analog, studied for its potential in growth hormone deficiencies and anti-aging.

Common Name:
CJC-1295

Compound Name:
CJC-1295 without DAC (Drug Affinity Complex)

Chemical Formula:
C152H252N44O42

Molecular Weight:
3367.97 g/mol

Sequence and Amino Acid Composition:

Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Amino Acid Profile:
- Tyrosine (Y):
  - Frequency: 2
  - Properties: Aromatic, hydrophobic, precursor to neurotransmitters
  - Role in the Peptide: Increases stability and interaction with growth hormone receptors
- Leucine (L) and Isoleucine (I):
  - Frequency: Multiple
  - Properties: Branched-chain amino acids, hydrophobic, essential for protein synthesis
  - Role in the Peptide: Crucial for structural integrity and function, enhancing binding affinity to GHRH receptors
- Arginine (R) and Lysine (K):
  - Frequency: Multiple
  - Properties: Positively charged, involved in protein interactions
  - Role in the Peptide: Key for signal transduction and stability in the bloodstream
- Others: Each amino acid is detailed similarly, indicating their frequency, chemical properties, and role in the peptide.

Structure:
CJC-1295 is a tetrasubstituted peptide of 29 amino acids, which is a modified version of the first 29 amino acids of GHRH, extended by a tail of amino acids to enhance the half-life of the peptide.

Synthesis Method:
Synthesized using solid-phase peptide synthesis, which ensures a precise arrangement of amino acids for high purity and biological specificity.

Solubility:
Soluble in sterile water and should be reconstituted with bacteriostatic water for long-term storage.

Stability:
Stable at refrigerated temperatures (2-8°C) when kept in lyophilized form. After reconstitution, it should be used within a week to maintain maximum potency.

Function:
CJC-1295 is a long-acting analog of growth hormone-releasing hormone (GHRH) that stimulates the release of growth hormone from the pituitary gland. It achieves this through binding to the GHRH receptor on pituitary cells.

Benefits and Uses:

Increases plasma levels of growth hormone, leading to enhanced muscle growth, fat loss, and recovery.
Used in anti-aging therapy, muscle development, and overall health improvement.
Research has also focused on its potential to improve deep wave sleep cycles, thereby enhancing restorative states of the organism.

Side Effects:
Common side effects include pain and irritation at the injection site, headaches, dizziness, and flushing. Long-term use can potentially lead to increased cortisol and acetylcholine production, which should be monitored.

Regulatory Status:
Not approved by the FDA for general medical use; available for research and clinical trials in various therapeutic applications.

CJC-1295

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