A peptide-based drug that contains neuropeptides and amino acids, promoting neuroprotection and neuroplasticity. It is studied for its efficacy in treating Alzheimer’s disease, traumatic brain injury, and other neurological conditions.
Common Name:
Cerebrolysin
Compound Name:
Cerebrolysin
Chemical Formula:
Not applicable; Cerebrolysin is a complex mixture of peptides derived from pig brain tissue.
Molecular Weight:
The specific molecular weights vary as Cerebrolysin is composed of different low-molecular-weight peptides and amino acids.
Sequence and Amino Acid Composition:
- Not applicable: Cerebrolysin is a mixture of peptides and free amino acids rather than a single peptide with a defined sequence.
Structure:
Cerebrolysin contains a variety of peptides and amino acids extracted from porcine brain tissue, which include fragments of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and other neuroactive peptides.
Synthesis Method:
Cerebrolysin is not synthesized but is extracted and purified from porcine brain tissue using enzymatic breakdown to create a complex mixture of biologically active peptides and free amino acids.
Solubility:
Soluble in water and physiological saline, suitable for injection.
Stability:
Stable under normal storage conditions when kept refrigerated. It should be used immediately once opened and any unused solution should be discarded.
Function:
Cerebrolysin is used for its neurotrophic and neuroprotective properties. It is believed to enhance neuronal growth and survival, improve synaptic connectivity, and support overall brain health and function.
Benefits and Uses:
- Used in the treatment of stroke, traumatic brain injuries, and Alzheimer’s disease due to its neuroprotective and regenerative capabilities.
- Employed in various neurological disorders to improve cognitive functions and reduce symptoms of neurodegeneration.
- Investigated for potential effects on mood, learning, and memory enhancement.
Side Effects:
Potential side effects can include dizziness, headache, agitation, and flu-like symptoms. In rare cases, allergic reactions might occur due to its biological origin.
Regulatory Status:
Cerebrolysin is approved for use in several countries outside the United States, primarily in Europe and Asia, for the treatment of stroke, Alzheimer’s disease, and other neurological conditions.
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