AOD-9604

A modified form of human growth hormone, AOD-9604 is studied for its ability to promote fat loss without affecting muscle mass or appetite. It works by mimicking the fat-burning effects of growth hormone.

Common Name:
AOD-9604

Compound Name:
Anti-Obesity Drug-9604

Chemical Formula:
C78H123N23O23S2

Molecular Weight:
1815.08 g/mol

Sequence and Amino Acid Composition:

• Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
• Amino Acid Profile:
  • Tyrosine (Y):
    • Frequency: 1
    • Properties: Aromatic, hydrophobic, precursor to neurotransmitters
    • Role in the Peptide: Enhances peptide stability and receptor interaction
  • Leucine (L), Arginine (R), and Valine (V):
    • Frequencies: Multiple
    • Properties: Essential amino acids, play significant roles in protein synthesis and metabolic signaling
    • Role in the Peptide: Critical for maintaining structural integrity and enhancing biological activity
  • Cysteine (C):
    • Frequency: 2
    • Properties: Forms disulfide bonds, stabilizing the peptide structure
    • Role in the Peptide: Essential for the correct folding and stability of the peptide

Structure:
AOD-9604 is a peptide fragment of the C-terminus of human growth hormone (hGH) from amino acids 176-191. It is structured to emulate the fat-reducing effects of hGH without its adverse effects.

Synthesis Method:
Synthesized using solid-phase peptide synthesis, ensuring high purity and accuracy in the amino acid sequence.

Solubility:
Soluble in water and most aqueous buffers, making it suitable for various formulations.

Stability:
Stable under refrigeration (2-8°C) for extended periods in lyophilized form. Once reconstituted, it should be used within a short period to maintain effectiveness.

Function:
AOD-9604 primarily functions by mimicking the way natural growth hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified hGH.

Benefits and Uses:

• Promotes fat loss and inhibits the transformation of non-fatty foods into body fat.
• Potential use in the treatment of obesity.
• Investigated for its regenerative properties related to muscle and cartilage repair.

Side Effects:
Reported side effects are minimal but may include mild symptoms at the injection site such as redness and discomfort.

Regulatory Status:
Not approved by the FDA for therapeutic use; available for research purposes and in some supplements.

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