A vasodilatory peptide with anti-inflammatory properties, it plays a role in reducing blood pressure and protecting cardiovascular tissues.

Common Name:
Adrenomedullin

Compound Name:
Adrenomedullin

Chemical Formula:
C173H267N51O50S2

Molecular Weight:
4028.9 g/mol

Sequence and Amino Acid Composition:

• Sequence: Ser-Arg-Ser-Asp-Lys-Gly-Tyr-Phe-His-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
• Amino Acid Profile:
  • Each amino acid contributes specific properties that influence the peptide’s structure, receptor interaction, and biological functions, particularly in cardiovascular and renal systems.

Structure:
Adrenomedullin is a peptide hormone with a complex structure that includes several key amino acids responsible for its activity, particularly those involved in receptor binding and activation.

Synthesis Method:
Adrenomedullin is synthesized naturally in the body by various tissues, including endothelial cells and vascular smooth muscle cells. For research and therapeutic use, it is typically produced via recombinant DNA technology.

Solubility:
Soluble in aqueous solutions, suitable for biological studies and therapeutic applications.

Stability:
Sensitive to degradation at room temperature; should be stored at low temperatures, typically -20°C or lower, in a lyophilized form to maintain stability.

Function:
Adrenomedullin acts as a potent vasodilator and has significant effects on diuresis and natriuresis. It plays a critical role in regulating blood pressure, vascular tone, and cellular growth. It also possesses anti-inflammatory properties and contributes to angiogenesis.

Benefits and Uses:

• Used in research settings to study its potential for treating hypertension, heart failure, and renal diseases.
• Investigated for its therapeutic potential in managing sepsis and acute pancreatitis due to its anti-inflammatory effects.
• Explored for its role in cancer therapy, particularly in targeting tumor growth and angiogenesis.

Side Effects:
As a potent vasodilator, excessive use of adrenomedullin can lead to hypotension and other cardiovascular disturbances. Its therapeutic applications must be carefully controlled and monitored.

Regulatory Status:
Currently not approved for clinical use; remains primarily in the research phase with ongoing investigations into its therapeutic applications.

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