Involved in tissue repair and regeneration, particularly noted for its role in healing injuries.
Common Name:
TB500
Compound Name:
Thymosin Beta-4
Chemical Formula:
C₂₀₄H₃₁₈N₅₆O₆₁S
Molecular Weight:
4514.04 g/mol
Sequence and Amino Acid Composition:
- Sequence: ACSDGHPKLKYPDTSIIFKKECN
- Amino Acid Profile:
- Alanine (A):
- Frequency: 2
- Properties: Non-polar, hydrophobic
- Role in the Peptide: Provides flexibility and plays a role in bioactive site structure
- Cysteine (C):
- Frequency: 2
- Properties: Polar, forms disulfide bonds
- Role in the Peptide: Critical for structural integrity through disulfide bonding
- Serine (S):
- Frequency: 2
- Properties: Polar, hydrophilic
- Role in the Peptide: Modulates protein interactions and stability
- Others: Each amino acid is listed with its frequency, properties, and specific role.
- Alanine (A):
Structure:
Thymosin Beta-4 is a small, globular protein. Its structure is crucial for its interaction with actin in tissue regeneration processes.
Synthesis Method:
TB500 is synthesized chemically via solid-phase peptide synthesis, which is common for small peptides.
Solubility:
Soluble in water and most aqueous buffers.
Stability:
Stable at room temperature for periods under 3 weeks. Best stored desiccated below -18°C. Once reconstituted, should be refrigerated at temperatures not to exceed 35°F.
Function:
Thymosin Beta-4 is involved in tissue repair, regulation of inflammation, and promotion of wound healing and cell migration.
Benefits and Uses:
- Promotes faster wound healing and reduced inflammation.
- Enhances muscle growth and repair.
- Potential applications in the treatment of myocardial damage, tissue repair, and in veterinary medicine.
Side Effects:
Limited data on side effects; however, possible effects may include minor local irritation at the injection site.
Regulatory Status:
Not currently approved by the FDA for general use; predominantly used in research settings and veterinary applications.
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