A synthetic peptide that stimulates the release of growth hormone, studied for anti-aging and growth disorders.

Common Name:
Sermorelin

Compound Name:
Sermorelin Acetate, GRF 1-29

Chemical Formula:
C149H246N44O42S

Molecular Weight:
3357.88 g/mol

Sequence and Amino Acid Composition:

• Sequence: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
• Amino Acid Profile:
  • Tyrosine (Y):
    • Frequency: 2
    • Properties: Aromatic, hydrophobic, precursors to neurotransmitters
    • Role in the Peptide: Enhances peptide stability and increases hormone receptor interaction
  • Leucine (L):
    • Frequency: 4
    • Properties: Branched-chain amino acid, important for protein synthesis
    • Role in the Peptide: Critical for maintaining the structural stability of the peptide and enhancing binding affinity to the receptor
  • Arginine (R):
    • Frequency: 3
    • Properties: Positively charged, involved in protein interactions
    • Role in the Peptide: Essential for signal transduction and peptide solubility
  • Other Amino Acids: Detailed similarly, indicating their frequency, chemical properties, and specific roles in the peptide.

Structure:
Sermorelin is a synthetic analog of the naturally occurring Growth Hormone-Releasing Hormone (GHRH). Its structure is designed to mimic the first 29 amino acids of the natural GHRH, which are essential for its biological activity.

Synthesis Method:
Synthesized through solid-phase peptide synthesis, allowing precise amino acid sequence arrangement and high purity.

Solubility:
Soluble in water and most aqueous buffers, facilitating easy administration.

Stability:
Sensitive to light and heat. Recommended storage in a lyophilized form at -20°C, protected from light. Once reconstituted, it should be used within a short period to maintain potency.

Function:
Sermorelin acts as a potent stimulator of growth hormone production from the anterior pituitary gland. It binds to the GHRH receptor, mimicking the effects of natural GHRH.

Benefits and Uses:

• Enhances growth hormone levels in the body, leading to increased muscle mass, decreased body fat, improved energy levels, and enhanced tissue repair.
• Used clinically for the diagnosis and treatment of growth hormone deficiency in children and as an anti-aging treatment in adults.
• Has potential benefits in improving sleep patterns, enhancing recovery from injuries, and boosting overall metabolic rates.

Side Effects:
Possible side effects can include injection site reactions, headaches, flushing, hyperactivity, and in some cases, antibody formation that may reduce its effectiveness.

Regulatory Status:
FDA-approved for diagnostic evaluation of pituitary function and also for increasing growth hormone in deficient pediatric patients.

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