A synthetic peptide with anxiolytic and cognitive-enhancing properties. It modulates the expression of brain-derived neurotrophic factor (BDNF) and has potential applications in treating anxiety and cognitive disorders.

Common Name:
Selank

Compound Name:
Selank

Chemical Formula:
C33H57N11O9

Molecular Weight:
751.9 g/mol

Sequence and Amino Acid Composition:

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
• Amino Acid Profile:
  • Threonine (T):
    • Frequency: 1
    • Properties: Polar and hydrophilic, facilitates phosphorylation
    • Role in the Peptide: Enhances the structural stability and solubility of the peptide.
  • Lysine (K) and Arginine (R):
    • Frequency: Each occurs once
    • Properties: Positively charged, essential for molecular interactions
    • Role in the Peptide: Critical for binding and signaling functions within biological systems.
  • Proline (P):
    • Frequency: 3
    • Properties: Cyclic structure, contributes to the rigidity and stability of the peptide structure
    • Role in the Peptide: Important for maintaining the conformation of the peptide, enhancing its resistance to enzymatic degradation.

Structure:
Selank is a synthetic heptapeptide, derived from the naturally occurring tetrapeptide Tuftsin. It possesses a stable structure that is resistant to enzymatic degradation, attributed largely to its high proline content.

Synthesis Method:
Synthesized via solid-phase peptide synthesis, ensuring high purity and precise control over the peptide sequence.

Solubility:
Soluble in water and physiological saline, making it suitable for injection and various pharmaceutical formulations.

Stability:
Stable at room temperature for short periods; however, it is recommended to store lyophilized or refrigerated for long-term preservation.

Function:
Selank is primarily known for its anxiolytic (anti-anxiety) effects in the central nervous system without sedative or negative cognitive effects. It modulates the expression of Interleukin-6 (IL-6) and influences the balance of T helper cell cytokines.

Benefits and Uses:

• Widely used for its anxiolytic properties, improving anxiety symptoms without causing dependency or withdrawal issues.
• Shown to enhance cognitive functions and memory processing.
• Investigated for potential immune-modulating activities, possibly aiding in the regulation of various immune responses.

Side Effects:
Selank is generally well-tolerated with minimal side effects reported. Some individuals may experience mild headache or fatigue initially.

Regulatory Status:
Approved in some Eastern European countries for the treatment of generalized anxiety disorder and stress management. It is still under investigation in other regions.

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