A peptide that targets and promotes cartilage repair, studied for its potential in treating osteoarthritis and other cartilage-related conditions.
Common Name:
PTD-DBM
Compound Name:
Protein Transduction Domain – Dvl-Binding Motif
Chemical Formula:
Chemical formula varies as PTD-DBM is a peptide modified with a functional domain designed for specific biological interactions.
Molecular Weight:
The molecular weight will depend on the specific sequence and modifications, typically in the range of small to medium-sized peptides.
Sequence and Amino Acid Composition:
- Sequence: Specific sequence details are proprietary but generally include a functional domain that facilitates the entry of the peptide into cells (protein transduction domain) coupled with a sequence that interacts with specific intracellular targets (Dvl-binding motif).
- Amino Acid Profile:
- The amino acid composition is designed to optimize cellular uptake and interaction with target proteins involved in signaling pathways, such as the Wnt signaling pathway, which is critical for hair follicle development and other regenerative processes.
Structure:
PTD-DBM is a synthetic peptide that includes a cell-penetrating peptide linked to a sequence that specifically binds to Dishevelled (Dvl) proteins. This structure enables it to effectively modulate signaling pathways intracellularly.
Synthesis Method:
Synthesized via solid-phase peptide synthesis, which allows for precise control over the amino acid sequence and high purity of the final product.
Solubility:
Generally soluble in aqueous buffers, facilitating its application in research and therapeutic formulations.
Stability:
Stable under standard peptide storage conditions; typically stored lyophilized at -20°C and reconstituted in sterile water or buffer before use.
Function:
PTD-DBM is designed to inhibit the binding of Dvl to the Axin complex, thereby modulating the Wnt/β-catenin signaling pathway. This modulation is critical for processes like hair growth and follicle development, making it a potential therapeutic agent for hair loss and other dermatological conditions.
Benefits and Uses:
- Investigated primarily for its potential to promote hair regrowth by enhancing the Wnt signaling pathway, which is crucial for hair follicle development and cycling.
- Potential applications in regenerative medicine, particularly in tissues where Wnt signaling plays a key role in maintaining tissue homeostasis and regeneration.
Side Effects:
As a research chemical, the full profile of side effects is not well established. However, targeted delivery to specific cells and minimizing systemic exposure are critical to reduce potential off-target effects.
Regulatory Status:
Currently not approved by regulatory bodies like the FDA; used primarily in research settings. Clinical trials would be necessary to establish its safety and efficacy for medical use.
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