Originally developed as a tanning agent, Melanotan II has shown potential in reducing appetite and promoting weight loss by activating melanocortin receptors involved in energy homeostasis.

Common Name:
Melanotan II

Compound Name:
Melanotan II

Chemical Formula:
C50H69N15O9

Molecular Weight:
1024.18 g/mol

Sequence and Amino Acid Composition:

• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
• Amino Acid Profile:
  • Nle (Norleucine):
    • Frequency: 1
    • Properties: Analog of leucine, non-polar
    • Role in the Peptide: Increases peptide stability and longevity in the circulatory system
  • Aspartic Acid (D):
    • Frequency: 1
    • Properties: Acidic, polar
    • Role in the Peptide: Important for the interaction with melanocortin receptors
  • Histidine (H):
    • Frequency: 1
    • Properties: Basic, precursor to neurotransmitters, involved in binding sites
    • Role in the Peptide: Plays a role in receptor binding and signaling
  • Phenylalanine (F), Arginine (R), Tryptophan (W), Lysine (K):
    • Properties and Roles: These amino acids contribute to the structural integrity and biological activity of the peptide, influencing its ability to stimulate melanogenesis.

Structure:
Melanotan II is a synthetic cyclic heptapeptide, an analog of the alpha-melanocyte-stimulating hormone (α-MSH), designed to enhance the body’s natural response to UV exposure and stimulate melanogenesis without direct sun exposure.

Synthesis Method:
Synthesized through solid-phase peptide synthesis, providing a high level of purity and control over the sequence.

Solubility:
Soluble in sterile water, making it suitable for subcutaneous injection.

Stability:
Stable at room temperature for short periods but should be stored refrigerated or frozen for long-term storage to maintain potency.

Function:
Melanotan II stimulates melanogenesis through melanocortin receptors, enhancing melanin production without direct sun exposure. This process results in tanning of the skin.

Benefits and Uses:

• Induces skin tanning.
• Potentially reduces the risk of skin cancer by increasing melanin in the skin without the need for UV exposure.
• Studied for its effects on libido enhancement and erectile function.

Side Effects:
Common side effects include facial flushing, increased libido, spontaneous erections, nausea, and appetite suppression. Users should monitor for any allergic reactions or excessive skin pigmentation changes.

Regulatory Status:
Not approved by the FDA for medical use; available primarily through research channels and not recommended for general use due to potential risks and side effects.

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