A tripeptide derived from alpha-melanocyte-stimulating hormone, studied for its anti-inflammatory properties.

Common Name:
KPV

Compound Name:
Lysine-Proline-Valine

Chemical Formula:
C16H30N4O3

Molecular Weight:
330.44 g/mol

Sequence and Amino Acid Composition:

• Sequence: Lys-Pro-Val
• Amino Acid Profile:
  • Lysine (K):
    • Frequency: 1
    • Properties: Positively charged, essential for growth and tissue repair
    • Role in the Peptide: Enhances immune function and may reduce inflammation.
  • Proline (P):
    • Frequency: 1
    • Properties: Cyclic structure, contributes to protein folding and stability
    • Role in the Peptide: Helps maintain the peptide’s structure and influences its interaction with cellular receptors.
  • Valine (V):
    • Frequency: 1
    • Properties: Branched-chain amino acid, hydrophobic
    • Role in the Peptide: Plays a critical role in energy production and muscle metabolism.

Structure:
KPV is a tripeptide with a straightforward linear structure, contributing to its stability and functionality in biological systems.

Synthesis Method:
Synthesized through solid-phase peptide synthesis, allowing for precise control over the sequence and high purity of the product.

Solubility:
Soluble in water and most aqueous buffers, facilitating its use in various medical and research applications.

Stability:
Stable at room temperature for short periods; for long-term storage, it should be kept in a cool, dry place or refrigerated.

Function:
KPV is known for its potent anti-inflammatory and immunomodulatory effects. It acts on various immune cells to modulate inflammatory responses and has shown potential in treating inflammatory and autoimmune diseases.

Benefits and Uses:

• Explored for its therapeutic potential in dermatological conditions like psoriasis and eczema due to its anti-inflammatory properties.
• Investigated for use in treating inflammatory bowel disease and other gastrointestinal disorders.
• Potential applications in wound healing and tissue repair due to its modulation of immune responses.

Side Effects:
Currently, KPV is considered safe with minimal reported side effects in research studies. However, more extensive clinical testing is needed to fully understand its safety profile.

Regulatory Status:
Not approved by major regulatory bodies for clinical use; primarily used in research settings.

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