A selective growth hormone secretagogue that promotes growth hormone release, studied for its growth-promoting effects without significant side effects.

Common Name:
Ipamorelin

Compound Name:
Ipamorelin

Chemical Formula:
C38H49N9O5

Molecular Weight:
711.86 g/mol

Sequence and Amino Acid Composition:

• Sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2
• Amino Acid Profile:
  • Histidine (H):
    • Frequency: 1
    • Properties: Essential amino acid, positively charged, imidazole side chain
    • Role in the Peptide: Participates in the binding to growth hormone secretagogue receptors (GHSR)
  • Phenylalanine (F):
    • Frequency: 1
    • Properties: Aromatic, hydrophobic, essential amino acid
    • Role in the Peptide: Enhances the overall hydrophobic interaction within the biological environments
  • Lysine (K):
    • Frequency: 1
    • Properties: Positively charged, involved in binding and structural roles in proteins
    • Role in the Peptide: Aids in solubility and interaction with negatively charged components of the receptor
  • Aib (Aminoisobutyric acid) and D-2Nal (D-2-Naphthylalanine) are non-standard amino acids that enhance the peptide’s stability and specificity.

Structure:
Ipamorelin is a pentapeptide with a sequence that includes both standard and non-standard amino acids, enhancing its specificity and stability in physiological conditions.

Synthesis Method:
Synthesized through solid-phase peptide synthesis, allowing for precise control over the peptide sequence and high purity.

Solubility:
Highly soluble in water and suitable for subcutaneous injection.

Stability:
Stable at room temperature for periods under 3 weeks. Best stored desiccated below -18°C. Once reconstituted, should be refrigerated at temperatures not to exceed 35°F.

Function:
Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist. It stimulates the pituitary gland to release growth hormone without significantly impacting levels of cortisol and prolactin.

Benefits and Uses:

• Promotes the release of growth hormone, leading to potential benefits such as increased lean muscle mass, reduced body fat, and improved recovery and repair from injuries.
• Used in research settings for studying growth hormone modulation and has potential therapeutic applications in conditions associated with low growth hormone levels.

Side Effects:
Generally well-tolerated with a low risk of side effects. Possible mild symptoms include headaches and injection site reactions.

Regulatory Status:
Not approved by the FDA for therapeutic use; available for research purposes only.

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