Stimulates the release of growth hormone, used in research for its anabolic and anti-aging effects.

Common Name:
GHRP-6

Compound Name:
Growth Hormone Releasing Peptide-6

Chemical Formula:
C46H56N12O6

Molecular Weight:
873.01 g/mol

Sequence and Amino Acid Composition:

• Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
• Amino Acid Profile:
  • Histidine (H):
    • Frequency: 1
    • Properties: Essential amino acid, positively charged, imidazole side chain
    • Role in the Peptide: Participates in the binding to growth hormone secretagogue receptors (GHSR)
  • Tryptophan (W):
    • Frequency: 2
    • Properties: Large, aromatic, essential for protein synthesis
    • Role in the Peptide: Critical for maintaining the peptide’s structural integrity and receptor interaction
  • Alanine (A):
    • Frequency: 1
    • Properties: Small, non-polar, helps in forming stable structures
    • Role in the Peptide: Adds flexibility to the peptide structure
  • Phenylalanine (F):
    • Frequency: 1
    • Properties: Aromatic, hydrophobic, essential amino acid
    • Role in the Peptide: Enhances the overall hydrophobic interaction within the biological environments
  • Lysine (K):
    • Frequency: 1
    • Properties: Positively charged, involved in binding and structural roles in proteins
    • Role in the Peptide: Aids in solubility and interaction with negatively charged components of the receptor.

Structure:
GHRP-6 is a hexapeptide with a sequence designed to mimic the natural growth hormone-releasing peptides.

Synthesis Method:
Synthesized using solid-phase peptide synthesis, ensuring high purity and the specific arrangement of amino acids.

Solubility:
Highly soluble in water and aqueous buffers, suitable for subcutaneous or intramuscular administration.

Stability:
Stable at room temperature for short periods. For long-term storage, peptides should be stored in lyophilized form at -20°C and reconstituted with bacteriostatic water before use.

Function:
Stimulates the pituitary gland to increase the production and release of growth hormone, influencing growth, metabolism, and body composition.

Benefits and Uses:

• Increases lean body mass, reduces body fat, enhances tissue growth.
• Used in the treatment of growth hormone deficiencies in both adults and children.
• Potential therapeutic implications in sports and anti-aging treatments.

Side Effects:
Possible side effects include water retention, increased hunger, symptoms of carpal tunnel syndrome, and possible increases in cortisol and prolactin levels.

Regulatory Status:
Not approved by the FDA for medical use; primarily used for research and clinical trials in various countries.

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