Often referred to as a “Botox-like” peptide, Argireline inhibits neurotransmitter release, reducing muscle contraction and the formation of expression lines and wrinkles.
Common Name:
Argireline
Compound Name:
Acetyl Hexapeptide-8
Chemical Formula:
C34H60N14O12S
Molecular Weight:
888.99 g/mol
Sequence and Amino Acid Composition:
- Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
- Amino Acid Profile:
- Glutamic Acid (E):
- Frequency: 2
- Properties: Polar and charged, enhancing peptide solubility and binding interactions.
- Role in the Peptide: Plays a crucial role in neurotransmitter release inhibition, which is key to Argireline’s mechanism of reducing muscle movement.
- Methionine (M) and Glutamine (Q):
- Properties: Methionine is sulfur-bearing, aiding in stability and bioactivity; Glutamine serves as a neurotransmitter and participates in enzymatic processes in the skin.
- Role in the Peptide: Contributes to the overall stability and efficacy of the peptide in skin applications.
- Arginine (R):
- Frequency: 2
- Properties: Positively charged, involved in signal transduction and enzyme interactions.
- Role in the Peptide: Enhances binding to the receptors that mediate neurotransmitter release, thus inhibiting the signals that cause muscle contractions.
- Glutamic Acid (E):
Structure:
Argireline is a synthetic hexapeptide with an acetyl group attached to the N-terminus, enhancing its solubility and skin penetration capabilities. It mimics the N-terminal end of the protein SNAP-25 and competes with this natural protein for a position in the SNARE complex, thereby moderating neurotransmitter release.
Synthesis Method:
Synthesized via solid-phase peptide synthesis, allowing precise control over the sequence and ensuring high purity necessary for cosmetic use.
Solubility:
Soluble in water and most cosmetic solvents, making it suitable for inclusion in various skincare formulations.
Stability:
Stable under normal storage conditions. It should be stored in a cool, dry place away from light to maintain its efficacy.
Function:
Argireline reduces the depth of wrinkles caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes. It inhibits the neurotransmitter release necessary for muscle contraction.
Benefits and Uses:
- Widely used in anti-aging cosmetic products to reduce facial wrinkles and lines.
- Commonly found in serums, creams, and lotions targeting expression lines.
- Offers a non-invasive alternative to procedures like Botox.
Side Effects:
Generally well-tolerated with minimal side effects. Some users may experience slight tingling or redness upon application, typically transient and mild.
Regulatory Status:
Recognized as a cosmetic ingredient in many countries. It is not subject to FDA approval but must comply with regulations concerning cosmetic safety and labeling.
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